APC Rabbit anti-Mouse CD138/Syndecan-1 mAb for FC - P18828

Core Product Specifications and Parameters

Biological Background: Syndecan-1 Function and Localization

• Syndecan-1, encoded by the Sdc1 gene, is a cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate chains, linking the cytoskeleton to the interstitial matrix. Related references: PMID:8163535
• It plays a role in exosome biogenesis through interaction with SDCBP and PDCD6IP (By similarity).
• Syndecan-1 can induce its own expression in dental mesenchymal cells and adjacent epithelial cells via an MSX1-mediated pathway. Related references: PMID:8898217
• The protein localizes to the plasma membrane as a transmembrane protein, and is also found in secreted forms and extracellular exosomes.
• Post‑translational modifications include heparan sulfate and chondroitin sulfate attachment, as well as phosphorylation (listed as a phosphoprotein).
• It belongs to the syndecan proteoglycan family and serves as a key mediator of cell‑matrix interactions.

Experimental Guidance and Technical Tips

• The immunogen (aa 23–255) corresponds to the extracellular domain of mouse Syndecan‑1, suggesting that this antibody may recognize an epitope exposed on live cells, making it suitable for surface staining in flow cytometry.
• As a rabbit monoclonal antibody with APC conjugation, it is ready for direct single‑color or multicolor flow cytometry protocols; appropriate compensation controls and isotype controls should be included.
• Since the antibody is validated on recombinant protein, performance should be verified in the relevant biological sample system, such as mouse cell lines or primary cells expressing Syndecan‑1.
• Cross‑reactivity is reported for mouse; for other species, check sequence homology before use.
• For intracellular staining or paraffin‑embedded tissue sections, additional validation may be required, as native conformation could be altered.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for IVD raw materials, offering validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents to support diagnostic development. For researchers focusing on cell surface proteoglycans, matrix biology, or exosome studies, this APC‑labeled anti‑mouse CD138 antibody provides a reliable flow cytometry tool. We also assist in sourcing rare‑target raw materials and providing technical consultancy to accelerate your project from concept to clinic.