APC Rabbit anti-Human/Monkey CD197/CCR7 Monoclonal Antibody for FC - P32248

Core Product Specifications and Parameters

Biological Background: CD197/CCR7 Function and Localization

• CD197/CCR7 is a C-C chemokine receptor type 7, also known as BLR2, EBI1 (EBV-induced G protein-coupled receptor 1), and MIP-3 beta receptor.
• It functions as a receptor for the chemokine MIP-3-beta and is a probable mediator of Epstein-Barr virus effects on B-lymphocytes and normal lymphocyte functions.
• CCR7 belongs to the G protein-coupled receptor family, characterized by seven transmembrane domains, disulfide bonds, and glycosylation.
• Subcellularly, the protein localizes to the cell membrane, consistent with its role as a membrane receptor.
• Tissue expression is prominent in various lymphoid tissues and activated B- and T-lymphocytes, with strong upregulation in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 25–59, which is part of the N-terminal extracellular domain, likely accessible for live-cell flow cytometry staining.
• Consider performing a titration to determine the optimal antibody concentration for your specific cell type and protocol.
• Validate the antibody in relevant sample systems such as human PBMCs, lymphoid cell lines, or cynomolgus monkey samples, based on the documented cross-reactivity.
• As an APC conjugate, direct application in flow cytometry is recommended without the need for secondary detection reagents.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supplies this APC Rabbit anti-Human/Monkey CD197/CCR7 monoclonal antibody as part of a broad portfolio of IVD-ready raw materials tailored for immunology and infectious disease research. From validated antibody pairs and optimized monoclonals to bulk ancillary reagents, we offer one-stop access to accelerate your diagnostic development—backed by extensive sourcing capabilities for even the most specialized targets.