APC Rabbit anti-Human mGluR2 Monoclonal Antibody for FC - Q14416

Core Product Specifications and Parameters

Biological Background: mGluR2 Function and Localization

• mGluR2 (metabotropic glutamate receptor 2) is a dimeric G protein-coupled receptor that serves as the primary receptor for the excitatory neurotransmitter L-glutamate. Related references: PMID:37286794
• Activation of mGluR2 modulates synaptic transmission and neuronal excitability by inhibiting presynaptic calcium channels and reducing further glutamate release (by similarity).
• The receptor signals via G proteins to down-regulate adenylate cyclase activity, and may be involved in synaptogenesis or synaptic stabilization.
• GRM2, the gene encoding mGluR2, is widely expressed in adult and fetal brain, with protein detection in the brain cortex.
• mGluR2 localizes to the cell membrane and is enriched at synaptic sites, including dendrites and dendritic projections.
• The receptor is post-translationally modified by disulfide bonds and glycosylation, with a predicted molecular weight of approximately 95.6 kDa.
• Notably, mGluR2 has been identified as a host entry factor for several viruses, including influenza virus, rabies virus, and SARS-CoV-2, which hijack its endocytosis for cell entry.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular domain (amino acids 22–498) of human mGluR2, which may improve specificity for native receptor detection in flow cytometry.
• For flow cytometry, consider optimizing antibody titration and using appropriate isotype controls and cell lines with known mGluR2 expression levels.
• Validate antibody reactivity in the relevant sample system (e.g., human brain tissue or peripheral immune cells) to confirm target recognition.
• Note that the antibody is conjugated to APC; ensure instrument compatibility and use appropriate compensation controls when combining with other fluorophores.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines the sourcing of high-quality IVD raw materials for diagnostic manufacturers and research institutes. This APC-conjugated anti-mGluR2 antibody supports neuroscience and infectious disease research, and CamelBio can also supply validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, or assist with sourcing rare-target raw materials for your diagnostic development pipeline.