APC Rabbit anti-Human CD153 Monoclonal Antibody for FC - P32971

Core Product Specifications and Parameters

Biological Background: CD153 Function and Localization

• CD153, also known as CD30 ligand (CD30L) or TNFSF8, is a member of the tumor necrosis factor (TNF) ligand superfamily.
• It is a type II transmembrane protein with a signal-anchor transmembrane helix, as indicated by UniProt keywords.
• The protein functions as a cytokine that specifically binds to the TNF receptor superfamily member CD30 (TNFRSF8).
• Upon binding to CD30, CD153 induces proliferation of T-cells, playing a role in immune regulation and lymphoid cell communication.
• According to UniProt, CD153 localizes to the membrane, consistent with its role as a cell-surface ligand.
• Key structural features include a disulfide bond and glycosylation, characteristic of secreted and membrane-bound cytokines.

Experimental Guidance and Technical Tips

• This antibody is directly conjugated to APC, eliminating the need for a secondary detection reagent in flow cytometry experiments.
• For optimal FC results, consider titrating the antibody to determine the best concentration for your specific cell type and instrument settings.
• Given the immunogen spans the extracellular domain (aa 63-234), the antibody is expected to recognize the native cell-surface CD153. Validate reactivity in your relevant sample system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides IVD manufacturers and research laboratories with integrated access to a broad portfolio of raw materials, including this anti-CD153 antibody for flow cytometry applications. Our supply capabilities extend to validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and customized sourcing for rare targets. Partner with CamelBio to streamline your procurement and accelerate development in immune cell analysis and diagnostic biomarker research.