APC Mouse anti-Human CD1a Monoclonal Antibody for Flow Cytometry - P06126

Core Product Specifications and Parameters

Biological Background: CD1a Function and Localization

• CD1a is a T-cell surface glycoprotein belonging to the CD1 family of antigen-presenting molecules.
• It binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells, contributing to adaptive immunity.
• The protein contains an immunoglobulin domain and a disulfide bond, and is subject to glycosylation.
• Subcellularly, CD1a localizes to the cell membrane, membrane rafts, and endosome membranes, consistent with its antigen-presenting function.
• Expression is predominantly on cortical thymocytes, epidermal Langerhans cells, and dendritic cells, with broader tissue distribution and presence in certain T-cell leukemias.

Experimental Guidance and Technical Tips

• This antibody is generated against a synthetic peptide from human CD1a and is validated for flow cytometry (FC). Always validate in your specific sample system.
• The APC conjugate enables direct detection in multicolor panels; confirm compatibility with your experimental setup.
• Given CD1a expression on thymocytes and dendritic cells, consider using appropriate cell lines or primary cells as positive controls.

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