APC Anti-CD66b Monoclonal Antibody for Flow Cytometry - P31997

Core Product Specifications and Parameters

Biological Background: CEACAM8 Function and Localization

• CD66b (CEACAM8) is a cell surface glycoprotein that mediates calcium-independent cell adhesion.
• It engages in heterophilic binding with other carcinoembryonic antigen-related cell adhesion molecules, including CEACAM6. Related references: PMID:11590190 | PMID:2022629 | PMID:8776764
• Heterophilic CEACAM8-CEACAM8 interactions take place on activated neutrophils. Related references: PMID:8776764
• The protein is a GPI-anchored, disulfide-bonded glycoprotein with immunoglobulin-like domains.
• It is primarily localized to the cell membrane and cell surface.
• CEACAM8 is expressed in leukocytes from chronic myeloid leukemia patients and in bone marrow.

Experimental Guidance and Technical Tips

• Consider titrating the antibody to determine the optimal working concentration for your flow cytometry panel.
• Validate reactivity in your specific sample system, such as whole blood, isolated neutrophils, or leukemia cell lines.
• Use appropriate single-color compensation controls when designing multicolor flow experiments with APC conjugates.
• Store the antibody protected from light at 2–8°C and avoid repeated freeze–thaw cycles to maintain conjugate stability.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with a comprehensive selection of IVD raw materials, including antibodies, antigens, and enzymes. For CD66b/CEACAM8-related assays, we offer validated antibody pairs, bulk reagents, and tailored sourcing support to accelerate your diagnostic development from concept to clinic.