Anti-ZNF711 Rabbit Polyclonal Antibody for WB, ELISA - Q9Y462

Core Product Specifications and Parameters

Biological Background: ZNF711 Function and Localization

• ZNF711, also referred to as ZNF6 or CMPX1, is a zinc finger transcription factor encoded by the ZNF711 gene in humans. It belongs to the krueppel C2H2-type zinc-finger protein family and is subject to alternative splicing.
• As a transcription regulator, ZNF711 is crucial for normal brain development. It localizes to the nucleus and binds to promoter regions of target genes, where it recruits the PHF8 histone demethylase to activate transcription of genes such as KDM5C. Related references: PMID:20346720 PMID:31691806
• ZNF711 may compete with the transcription factor ARX for the regulation of KDM5C expression, influencing neuronal gene expression programs. Related references: PMID:31691806
• The protein contains multiple zinc finger domains, providing DNA-binding capability, and is subject to post-translational modifications including isopeptide bond formation and ubiquitination.
• ZNF711 is specifically expressed in neural tissues, consistent with its role in brain development and function.
• Mutations in the ZNF711 gene are associated with X-linked intellectual disability, underscoring its importance in cognitive development.
• The predicted molecular weight of ZNF711 is approximately 86 kDa, as confirmed by UniProt.

Experimental Guidance and Technical Tips

• For Western blot analysis, a band around 86 kDa is expected for endogenous ZNF711 in human neural tissue lysates. Consider using appropriate controls and optimizing antibody dilution.
• In ELISA applications, validate the antibody using the immunizing peptide or recombinant ZNF711 protein to ensure specificity.
• Given the neural-specific expression, include brain or neural cell line samples for positive detection, and use knockout or knockdown controls to confirm target specificity.
• The antibody's polyclonal nature may provide robust signal but should be carefully characterized in each application.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for IVD raw materials, delivering validated antibody pairs, optimized recombinant proteins, and ancillary reagents from discovery through clinical application. For neuroscience and genetic disease research, our portfolio includes high-quality antibodies against transcription regulators like ZNF711, supporting diagnostic development and basic research. Rely on CamelBio to streamline your supply chain with rigorous quality and technical support.