Anti-ZNF652 Polyclonal Antibody for WB, ELISA - Q9Y2D9

Core Product Specifications and Parameters

Biological Background: ZNF652 Function and Localization

• ZNF652 is a C2H2-type zinc finger protein that acts as a DNA-binding transcription factor.
• It functions as a transcriptional repressor, specifically recognizing the consensus DNA sequence 5'-CGAAAGGGTTAAT-3' and cooperating with CBFA2T2 to silence targets like TCF12. Related references: PMID:16966434 PMID:18456661 PMID:21678463
• The protein localizes to the nucleus.
• ZNF652 is a phosphoprotein, and its activity may be regulated by post-translational modifications.
• It is widely expressed, with higher levels in breast, prostate, vulva, and pancreas.
• Key structural features include multiple zinc-finger domains, metal-binding sites, and a repressor domain.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1–74) of human ZNF652; thus, the antibody is expected to recognize epitopes within this domain.
• For Western blotting, a band at ~70 kDa should be observed; using nuclear extracts may improve signal intensity.
• Validate specificity by siRNA knockdown or peptide competition in your experimental system.
• For ELISA, consider optimizing coating conditions and detection antibody concentrations based on assay format.

CamelBio: Your One-Stop Sourcing Bridge

As a partner in IVD development, CamelBio supports researchers and manufacturers in transcription regulation studies by supplying this high-quality anti-ZNF652 antibody. We offer a full portfolio of validated antibody pairs, optimized polyclonal and monoclonal antibodies, and bulk ancillary reagents. For rare or custom targets, our sourcing service ensures timely access to raw materials, backed by technical consulting from concept to clinic.