Anti-ZNF408 Rabbit pAb for WB, ELISA - Q9H9D4

Core Product Specifications and Parameters

Biological Background: ZNF408 Function and Localization

• ZNF408, also known as PR domain zinc finger protein 17 (PRDM17), is a member of the zinc finger protein family and contains a PR domain along with multiple C2H2-type zinc fingers, suggesting a role in DNA binding and transcriptional regulation.
• The protein may be involved in transcriptional regulation, potentially acting as a transcription factor.
• ZNF408 is localized primarily in the nucleus, consistent with its predicted role in gene regulation.
• Highest expression is observed in adult retina, especially in cone and rod photoreceptor cells, as well as in the ganglion cell layer and plexiform layers. It is also abundantly expressed in the fetal eye and retinal blood vessels.
• Classified as a phosphoprotein, indicating that its activity may be regulated by phosphorylation.
• Associated with disease variants linked to retinitis pigmentosa, highlighting its importance in retinal health and disease.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a C-terminal region (residues 471-720) of human ZNF408, which may help reduce cross-reactivity with other zinc finger proteins that share similar domains.
• For Western blotting, the predicted molecular weight is approximately 78 kDa; consider using appropriate gel percentage and transfer conditions for proteins of this size.
• The antibody is applicable to human, mouse, and rat samples; validate detection in the relevant species and tissue type, noting high expression in retina.
• For ELISA applications, optimization of coating antigen and antibody concentration is recommended to achieve optimal signal-to-noise ratio.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with one-stop access to high-quality IVD raw materials, including validated polyclonal antibodies like this anti-ZNF408 product. Supporting applications in transcriptional regulation and retinal disease research, we offer optimized antibodies, bulk reagents, and rare target sourcing to streamline your development pipeline. Our comprehensive supply capabilities also encompass validated antibody pairs and ancillary reagents, ensuring you have a reliable sourcing partner from concept to clinic.