Anti-ZNF346 Rabbit Polyclonal Antibody for WB and ELISA - Q9UL40

Core Product Specifications and Parameters

Biological Background: ZNF346 Function and Localization

• ZNF346, also known as Just Another Zinc finger protein (JAZ), is a zinc finger protein that contains four C2H2-type zinc finger repeats, placing it in the broad family of nucleic acid-binding proteins.
• It binds with low affinity to double-stranded DNA and single-stranded RNA, and with high affinity to double-stranded RNA, showing no detectable sequence specificity. Related references: PMID:24521053
• ZNF346 may also bind to specific miRNA hairpins, suggesting a role in post-transcriptional gene regulation. Related references: PMID:28431233
• The protein localizes to the nucleus, nucleolus, and cytoplasm, indicating dynamic shuttling and functional versatility in different cellular compartments.
• Post-translational modifications include acetylation, isopeptide bond formation, and ubiquitin conjugation, as identified by proteomics studies.
• Alternative splicing of the ZNF346 gene produces multiple isoforms, potentially expanding its functional repertoire.

Experimental Guidance and Technical Tips

• The immunogen covers the full-length human ZNF346 protein (residues 1–294), making this polyclonal antibody suitable for detecting native and recombinant protein with proper folding.
• For Western blot analysis, consider using cell or tissue lysates from human, mouse, or rat as positive controls, and validate the band size against the predicted molecular weight of ~33 kDa.
• In ELISA assays, optimize the coating concentration by titration against known amounts of target antigen; this antibody is recommended as a detection reagent, but direct labeling or pairing should be validated experimentally.
• As a polyclonal antibody, lot-to-lot consistency should be verified in each specific assay system, and cross-adsorption steps may be considered to reduce background in highly sensitive applications.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as your comprehensive partner for IVD raw-material procurement, supporting every stage from concept to clinic. Our portfolio features validated polyclonal antibodies such as anti-ZNF346, optimized for WB and ELISA, and we specialize in sourcing monoclonal antibodies, matched antibody pairs, and bulk ancillary reagents for RNA-binding protein research. Contact us to streamline your diagnostic development with reliable, bulk-supplied raw materials and expert technical consulting.