Anti-ZNF141 Polyclonal Antibody for IHC-P, ELISA - Q15928

Core Product Specifications and Parameters

Biological Background: ZNF141 Function and Localization

• ZNF141 (Zinc finger protein 141) belongs to the C2H2-type zinc finger protein family, featuring multiple zinc finger repeats that enable sequence-specific DNA binding.
• Acts as a transcriptional repressor, potentially downregulating target gene expression during key developmental windows.
• Critically involved in limb development, with functional evidence pointing to a role in morphogenetic signaling.
• Exclusively localizes to the nucleus, consistent with its DNA-binding and transcription regulation activities.
• Ubiquitously expressed at low levels across tissues, suggesting a broad but tightly controlled regulatory function.
• Contains metal-binding zinc finger domains; classified under nucleic acid-binding proteins with repressor activity.
• Associated with developmental pathways and disease variants (though specific pathogenic links require further characterization).

Experimental Guidance and Technical Tips

• For IHC-P, consider optimizing antigen retrieval conditions and titrating the antibody concentration for each tissue type; the immunogen spans amino acids 405–474, which may influence epitope accessibility in fixed samples.
• In ELISA setups, use the recombinant immunogen as a positive control to confirm antibody reactivity and establish baseline performance.
• Being a polyclonal antibody, monitor for batch-to-batch consistency; incorporate appropriate negative controls to ensure specificity.
• Cross-reactivity with mouse and rat allows translational studies, but always validate expression levels in the chosen model system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines procurement of IVD raw materials, offering validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents for transcriptional regulation and developmental biology applications. Our sourcing network excels in rare-target access, ensuring reliable supply of ZNF141-specific reagents for research and diagnostic development. Count on us as a single partner to bridge your workflow from concept to clinic.