Anti-ZMYND11 Polyclonal Antibody for WB, ELISA - Q15326

Core Product Specifications and Parameters

Biological Background: ZMYND11 Function and Localization

• ZMYND11 (Zinc finger MYND domain-containing protein 11), also known as BS69 or BRAM1, is a chromatin reader that specifically recognizes histone H3.3 trimethylated at Lys-36 (H3.3K36me3), distinguishing it from canonical H3.1/H3.2.
• It functions as a transcription corepressor by modulating RNA polymerase II elongation at highly expressed genes.
• ZMYND11 binds non-specifically to double-stranded DNA, as demonstrated in vitro. Related references: PMID:24675531
• Acts as a tumor suppressor by repressing a transcriptional program essential for tumor cell growth.
• Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation during infection.
• Localizes predominantly to the nucleus and associates with chromosomes.
• Ubiquitously expressed across tissues.
• Contains a bromodomain and a MYND-type zinc finger domain; alternative splicing produces multiple isoforms.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 278–567 of human ZMYND11, spanning the MYND domain and adjacent regions; consider this when predicting epitope accessibility in different applications.
• Recommended for Western blot (WB) detection of endogenous ZMYND11 (predicted ~71 kDa) in human and mouse cell lysates; include appropriate controls and validate in your sample system.
• ELISA may be used to assess antibody titer or to screen for antigen binding; optimization of coating and detection conditions is advised.
• For immunofluorescence or other untested applications, pilot experiments are recommended to determine suitability.

CamelBio: Your One-Stop Sourcing Bridge

As your one-stop IVD raw-material sourcing partner, CamelBio supports diagnostic and life science manufacturers with validated antibody pairs, bulk ancillary reagents, and rare target raw materials. This anti-ZMYND11 polyclonal antibody is part of our expanding catalog for epigenetic and oncology research tools. Contact us for customized sourcing and technical consultation across the development pipeline.