Anti-ZMAT2 Rabbit Polyclonal Antibody for WB, ELISA - Q96NC0

Core Product Specifications and Parameters

Biological Background: ZMAT2 Function and Localization

• ZMAT2 is a zinc finger matrin-type protein that functions as a component of the spliceosome, playing a critical role in pre-mRNA splicing.
• It possesses zinc-finger domains that facilitate DNA-binding and metal-binding, essential for its structural and functional roles.
• ZMAT2 is localized in the nucleus, consistent with its involvement in nuclear mRNA processing events.
• The protein undergoes post-translational modifications including acetylation and ubiquitin-like conjugation (Ubl), which may regulate its activity and interactions.
• As a reference proteome component, ZMAT2 has been identified in proteomics studies, underscoring its expression in human cells.
• Keywords associated with ZMAT2 include: spliceosome, mRNA processing, mRNA splicing, DNA-binding, and zinc-finger, highlighting its key biological themes.

Experimental Guidance and Technical Tips

• The immunogen corresponds to full-length human ZMAT2 (aa 1-199), suggesting potential recognition of the native protein in denaturing and native conditions (WB and ELISA).
• For Western blot, consider using nuclear extracts from human, mouse, or rat cell lines, as ZMAT2 is a nuclear protein (predicted MW ~24 kDa).
• In ELISA applications, ensure the antibody is titrated appropriately; cross-reactivity with mouse and rat orthologs may require validation in your specific assay system.
• As a spliceosome component, ZMAT2 expression may vary across tissues; include appropriate positive and negative controls.
• Since this is a polyclonal antibody, lot-to-lot consistency should be assessed for critical quantitative applications.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with streamlined access to high-quality IVD raw materials, including validated antibodies for splicing factors like ZMAT2. Our extensive portfolio covers optimized polyclonal and monoclonal antibodies, bulk ancillary reagents, and custom sourcing for rare targets, supporting your assay development from concept to clinic. For your splicing research needs, contact us to explore our one-stop supply solutions.