Anti-ZMAT2 Polyclonal Antibody for WB, ELISA - Q96NC0

Core Product Specifications and Parameters

Biological Background: ZMAT2 Function and Localization

• ZMAT2 is a zinc finger matrin-type protein 2, characterized by a zinc finger domain that confers DNA-binding and metal-binding properties.
• Encoded by the ZMAT2 gene, it functions as an integral component of the spliceosome, essential for pre-mRNA splicing.
• As part of the mRNA processing machinery, ZMAT2 facilitates accurate intron removal and exon ligation during mRNA maturation.
• Subcellularly, ZMAT2 localizes to the nucleus, consistent with its role in nucleic acid processing.
• Post-translational modifications include acetylation and ubiquitination (via isopeptide bonds), which may regulate its stability or protein interactions.
• High-resolution 3D structures provide insights into its domain organization and potential molecular interfaces.
• Proteomic profiling has confirmed its presence in physiologically relevant spliceosomal complexes.

Experimental Guidance and Technical Tips

• The immunogen spans full-length ZMAT2 (amino acids 1–199), so the antibody likely detects the native protein; include appropriate positive and negative controls.
• For Western blot (WB), the predicted molecular weight is 24 kDa; select an SDS-PAGE gel percentage sufficient to resolve proteins in this range.
• Cross-reactivity reported for human, mouse, and rat suggests broad species applicability; however, validation in the relevant sample system is recommended.
• For ELISA, titrate the antibody to determine optimal coating antigen concentration and detection conditions.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive one-stop sourcing partner for IVD raw materials, offering validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents to diagnostic manufacturers and research laboratories. This anti-ZMAT2 polyclonal antibody supports investigations into spliceosome function and pre-mRNA splicing mechanisms. From early research to clinical translation, CamelBio delivers reliable supply and technical support to streamline your workflow.