Anti-ZIC3 Polyclonal Antibody for WB and ELISA - O60481

Core Product Specifications and Parameters

Biological Background: ZIC3 Function and Localization

• ZIC3 (Zinc finger protein ZIC 3), also known as ZNF203, is a C2H2-type zinc finger transcription factor.
• It acts as a transcriptional activator and binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
• ZIC3 is essential for the earliest stages of axial midline development and left-right asymmetry specification.
• The protein is predominantly localized in the nucleus but can also be found in the cytoplasm.
• It is implicated in developmental processes, including neurogenesis and differentiation.
• Keywords associated with ZIC3 include DNA-binding, metal-binding, zinc-finger repeat, and transcription regulation.
• Genetic variants in ZIC3 are linked to heterotaxy and other congenital anomalies.

Experimental Guidance and Technical Tips

• The recombinant immunogen covering amino acids 1-240 of human ZIC3 targets the N-terminal region; verify target band at ~51 kDa in your experimental setting.
• For Western blot, consider appropriate loading controls and confirm specificity using knockout or knockdown controls if available.
• ELISA applications can be useful for antibody titer determination or quantitative detection of ZIC3.
• Cross-reactivity is reported for human, mouse, and rat; perform validation if using other species.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop partner for sourcing ZIC3 antibodies and related IVD raw materials for developmental biology and transcription research. We offer validated polyclonal and monoclonal antibody options, bulk ancillary reagents, and rare target sourcing to support assay development from concept to clinic. Contact us to explore customized solutions for your ZIC3 detection needs.