Anti-ZDHHC8 Rabbit Polyclonal Antibody for WB, ELISA - Q9ULC8

Core Product Specifications and Parameters

Biological Background: ZDHHC8 Function and Localization

• ZDHHC8 (DHHC-8) is a palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, regulating their localization and function.
• It palmitoylates ABCA1, regulating its plasma membrane localization and function in cholesterol and phospholipid efflux.
• It also palmitoylates the D2 dopamine receptor DRD2, modulating its stability and plasma membrane localization.
• ZDHHC8 is involved in glutamatergic transmission (by similarity).
• It plays a role in host-virus interaction: palmitoylates SARS-CoV-2 spike protein, promoting spike biogenesis, protecting from ER degradation, and controlling fusion with target cells.
• The protein is a multi-pass membrane protein localized to the Golgi apparatus and mitochondrial membranes.
• It is widely expressed in tissues.
• Post-translational modifications include methylation and phosphorylation.

Experimental Guidance and Technical Tips

• The immunogen (amino acids 240-380) corresponds to a region of ZDHHC8. Consider verifying reactivity with the full-length protein in the relevant species.
• For Western blotting, expect a band near 81 kDa. Include proper controls to confirm specificity.
• The antibody cross-reacts with mouse ZDHHC8; consider using mouse cell lines or tissues for model organism studies.
• For ELISA, optimize coating antigen and antibody dilutions as per your assay conditions.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This ZDHHC8 rabbit polyclonal antibody supports research into protein palmitoylation, cholesterol metabolism, and viral host interactions. Explore our portfolio of validated antibodies, recombinant proteins, and ancillary reagents to accelerate your assay development.