Anti-ZBTB17 Polyclonal Antibody for WB and ELISA - Q13105

Core Product Specifications and Parameters

Biological Background: ZBTB17 Function and Localization

• Also known as MIZ-1, ZNF151, and ZNF60, ZBTB17 is a transcription factor that can function as either an activator or repressor depending on its binding partners and the cellular context.
• Plays a critical role in early lymphocyte development by preventing apoptosis in lymphoid precursors, enabling them to survive in response to IL7 and undergo proper lineage commitment.
• Binds to the promoters of adenovirus major late protein and cyclin D1, thereby activating transcription.
• Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3. Related references: PMID:25245946
• Required for early embryonic development during gastrulation.
• Localizes to the nucleus where it exerts its transcriptional functions.
• Expressed in germinal center B-cells, consistent with its role in lymphocyte biology.
• Contains BTB and zinc finger domains; subject to phosphorylation and ubiquitination, classified as a DNA-binding, metal-binding phosphoprotein with isopeptide bonds.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 121–360 of human ZBTB17, a region likely to be accessible for antibody binding. Consider using the recombinant fusion protein as a positive control in assays.
• Predicted molecular weight is 88 kDa; for Western blot, validate the specific band size in your sample system and consider loading appropriate positive and negative controls.
• Cross-reactivity with mouse and rat indicates conserved epitopes; however, validation in the specific tissue or cell line is recommended before interpreting results.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio specializes in providing diagnostic manufacturers, laboratories, and research institutes with comprehensive access to IVD raw materials, including validated antibody pairs and optimized monoclonal/polyclonal antibodies like this ZBTB17 polyclonal antibody. Whether you need bulk ancillary reagents, customized antibody sourcing, or rare target raw materials, CamelBio is your reliable partner to bridge from concept to clinic. Rely on our supply expertise to support your transcription factor research and lymphocyte development studies with trusted, consistent material.