Anti-YY2 Polyclonal Antibody for WB, IF/ICC, ELISA - O15391

Core Product Specifications and Parameters

Biological Background: YY2 Function and Localization

• YY2 (Yin and yang 2), also known as zinc finger protein 631 (ZNF631), is a transcription factor belonging to the zinc finger protein family.
• Functions as a multifunctional transcription factor, exhibiting both positive and negative regulation on a large number of genes.
• Antagonizes the activity of YY1, playing a role in development and differentiation.
• Localizes to the nucleus as a DNA-binding protein.
• Contains zinc finger motifs, enabling sequence-specific DNA binding and transcriptional regulation.
• Predicted molecular weight is approximately 41 kDa (UniProt: 41347 Da).
• Expressed in kidney, liver, spleen, and testis, but not in colon.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide corresponding to amino acids 200-300 of human YY2; verify sequence conservation in mouse and rat for cross-reactivity.
• For Western blot, the predicted molecular weight is ~41 kDa; consider using appropriate positive control lysates from human, mouse, or rat tissues known to express YY2 (kidney, liver, spleen, testis).
• For immunofluorescence/ICC, confirm nuclear localization as expected.
• Validate antibody performance in the relevant sample system and application prior to routine use.

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CamelBio offers comprehensive IVD raw material solutions, including validated antibody pairs and monoclonal/polyclonal antibodies for transcription factor research like YY2. We support diagnostic manufacturers and labs with one-stop access to bulk reagents and rare target sourcing, streamlining your development from concept to clinic.