Anti-WBP11 Rabbit Polyclonal Antibody for WB, IHC-P, IF/ICC, ELISA - Q9Y2W2

Core Product Specifications and Parameters

Biological Background: WBP11 Function and Localization

• WW domain-binding protein 11, also known as Npw38-binding protein (NpwBP), SH3 domain-binding protein SNP70, and splicing factor that interacts with PQBP-1 and PP1.
• Activates pre-mRNA splicing and may inhibit protein phosphatase 1 (PP1) phosphatase activity.
• Localizes to both the nucleus and the cytoplasm.
• Ubiquitously expressed; highly expressed at protein level in heart, pancreas, kidney, skeletal muscle, placenta, and brain; weakly expressed in liver and lung.
• Post-translationally modified by acetylation, methylation, phosphorylation, isopeptide bond formation, and Ubl conjugation, indicating tight regulatory control.
• Involved in mRNA processing and splicing, as well as rRNA processing, according to UniProt keywords.
• Associated with disease variants, highlighting its potential clinical relevance.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 540–641 near the C-terminus of human WBP11. Consider validating detection of full-length protein and any relevant isoforms in your sample system.
• For Western blot, the predicted molecular weight is approximately 70 kDa. Optimize lysate preparation and antibody dilution for human, mouse, or rat tissues as cross-reactivity data indicate recognition across these species.
• IHC-P may require antigen retrieval and careful titration. Test on positive control tissues known to highly express WBP11 (e.g., heart, pancreas).
• This antibody is also reported for IF/ICC and ELISA, but optimal working concentrations should be determined empirically by the end user.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio partners with diagnostic manufacturers, labs, and research institutes to streamline raw‑material procurement—from concept to clinic. This anti‑WBP11 polyclonal antibody fits into splicing research workflows, and our portfolio also includes validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and custom sourcing for rare targets. Reach out to explore how our integrated supply solutions can support your next project.