Anti-UTP6 Polyclonal Antibody for WB, ELISA - Q9NYH9

Core Product Specifications and Parameters

Biological Background: UTP6 Function and Localization

• UTP6, also known as HCA66 (Hepatocellular carcinoma-associated antigen 66) and Multiple hat domains protein, is encoded by the UTP6 gene (C17orf40, MHAT) in humans.
• It is a component of the small subunit (SSU) processome, which is the first precursor of the small eukaryotic ribosomal subunit.
• Involved in nucleolar processing of pre-18S ribosomal RNA, playing a critical role in ribosome biogenesis.
• Functions within the nucleolus to facilitate RNA folding, modifications, rearrangements, cleavage, and targeted degradation of pre-ribosomal RNA by the RNA exosome.
• Subcellular localization is primarily nuclear, concentrated in the nucleolus.
• Contains multiple hat domains, annotated as repeats, and its structure has been partially characterized (3D-structure keyword).
• Identified in proteomics studies (Proteomics identification keyword), indicating widespread detection in human cells.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1-220). Consider epitope mapping or validation with full-length and truncated protein systems.
• For Western blot, an expected band at approximately 70 kDa can be verified in human, mouse, and rat cell lysates.
• For ELISA assays, consider coating with recombinant UTP6 protein or using cell extracts; validate assay conditions in the relevant sample matrix.
• Because UTP6 is nucleolar, subcellular fractionation may enhance detection sensitivity in some experimental setups.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a one-stop sourcing partner for IVD raw materials, offering validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents. For ribosome biogenesis and nucleolar research, we provide reliable anti-UTP6 antibodies and can assist with rare target raw-material sourcing. Contact us to streamline your assay development from concept to clinic.