Anti-USP26 Polyclonal Antibody for WB, ELISA - Q9BXU7

Core Product Specifications and Parameters

Biological Background: USP26 Function and Localization

• USP26 is a deubiquitinating enzyme belonging to the ubiquitin-specific protease (USP) family, characterized by its thiol protease activity, and is encoded by the USP26 gene.
• It functions as a key regulator of somatic cell reprogramming by deubiquitinating and stabilizing CBX4 and CBX6, components of the polycomb-repressive complex 1 (PRC1), via Lys-48-linked deubiquitination (PubMed:28839133). Related references: PMID:28839133
• USP26 deubiquitinates and stabilizes the androgen receptor (AR), thereby modulating the androgen receptor signaling pathway (PubMed:20501646). Related references: PMID:20501646
• It is suggested to play a role in spermatogenesis, supported by its expression in testis and involvement in male fertility (PubMed:34202084). Related references: PMID:34202084
• Subcellularly, USP26 localizes primarily to the nucleus but is also found in the cytoplasm and associated with the flagellum axoneme, indicating potential roles in cell projection and ciliary functions.
• It is a thiol protease involved in the ubiquitin conjugation pathway, and its expression is enriched in testis, highlighting its tissue-specific regulation.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 664 – 913 of human USP26; consider that the antibody may also recognize C‑terminal fragments or isoforms.
• For Western blotting, denaturing and reducing conditions are recommended; include appropriate positive (e.g., testis lysate) and negative controls.
• Validate the antibody in the relevant sample system (human, mouse, or rat), as cross‑reactivity data indicate conservation of the epitope across these species.
• For ELISA, immobilize the antigen using a standard protocol; using recombinant USP26 as a reference standard can aid quantification.
• Always follow general laboratory practices for antibody handling and titration.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with a one‑stop access to IVD raw materials, technical services, and consulting — from concept to clinic. This USP26 polyclonal antibody is part of our portfolio for studying deubiquitination, androgen signaling, and male fertility. We also offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and custom sourcing for rare targets to streamline your diagnostic and research workflows.