Anti-USP24 Rabbit Polyclonal Antibody for WB, ELISA - Q9UPU5

Core Product Specifications and Parameters

Biological Background: USP24 Function and Localization

• USP24 (Ubiquitin carboxyl-terminal hydrolase 24) is a deubiquitinating enzyme, also known as Ubiquitin thioesterase 24 or Ubiquitin-specific-processing protease 24.
• It functions as a ubiquitin-specific protease, modulating the stability of substrates such as DDB2, MCL1, and TP53 to regulate cell survival.
• USP24 promotes ferritinophagy, the autophagic degradation of ferritin in lysosomes, releasing free iron.
• Classified as a thiol protease, USP24 participates in the ubiquitin conjugation pathway.
• It is identified as a phosphoprotein and has been implicated in host-virus interactions.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a C-terminal region (amino acids 2431–2620); consider epitope accessibility in your assay design.
• For Western blotting, use low-percentage polyacrylamide gels and extended transfer times to accommodate the large ~294 kDa protein.
• Validate antibody reactivity in relevant human and mouse sample systems with appropriate positive and negative controls.
• For ELISA, optimize coating antigen concentrations and antibody dilutions under your specific experimental conditions.

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CamelBio serves as a comprehensive sourcing partner for IVD raw materials, offering validated polyclonal antibodies like anti-USP24 for diagnostic and research applications. Our portfolio includes bulk ancillary reagents and rare-target antibody pairs to streamline your assay development. Leverage our one-stop supply chain to accelerate your USP24-related projects from concept to clinic.