Anti-Urocortin-2 (UCN2) Rabbit Polyclonal Antibody for WB and ELISA - Q96RP3

Core Product Specifications and Parameters

Biological Background: Urocortin-2 (UCN2) Function and Localization

• UCN2, also known as stresscopin-related peptide, urocortin II, and urocortin-related peptide, is a member of the corticotropin-releasing hormone (CRH) family of peptides (PubMed:11329063). Related references: PMID:11329063
• It functions as a hormone central to whole-body adaptation to stress, acting by binding to the CRH receptor CRHR2 (PubMed:20966082). Related references: PMID:20966082
• UCN2-dependent signaling regulates cardiovascular function, promotes skeletal muscle hypertrophy, manages energy balance, and exerts anorexigenic effects (By similarity).
• Unlike CRH and urocortin, UCN2 does not stimulate the hypothalamus-pituitary-adrenal axis or adrenocorticotropic hormone (ACTH) production (PubMed:11329063). Related references: PMID:11329063
• The protein is secreted and classified as a hormone with a signal peptide, and a three-dimensional structure has been determined.
• It is encoded by the UCN2 gene, which has been associated with stress-related disorders and metabolic regulation.

Experimental Guidance and Technical Tips

• The immunogen used is a recombinant fusion protein corresponding to amino acids 20–112 of human UCN2, which encompasses the mature peptide region; the antibody may therefore recognize the secreted form of the protein.
• For Western blotting, the predicted molecular weight is approximately 12 kDa; use appropriate gel concentration and PVDF membranes with low-molecular-weight protein detection capabilities.
• The antibody is reported to cross-react with human, mouse, and rat UCN2; validation in the relevant sample matrix and species is recommended.
• For ELISA applications, the polyclonal nature can provide multi-epitope recognition, potentially enhancing signal; optimal dilution should be determined experimentally.
• Given the hormone's stress-inducible nature, consider appropriate physiological conditions or stimulation protocols for sample preparation to capture dynamic expression.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers, laboratories, and research institutes a comprehensive, one-stop solution for IVD raw material procurement, technical services, and project consulting—guiding projects from initial concept to clinical application. For researchers focused on stress biology, cardiovascular function, and metabolic disorders, CamelBio can supply validated antibody pairs, optimized polyclonal antibodies like this anti-UCN2 product, and bulk ancillary reagents to support your assay development. We also specialize in sourcing rare-target raw materials, helping you secure critical tools for niche biomarkers such as urocortin-2.