Anti-UQCRC1 Rabbit Polyclonal Antibody for WB, IHC-P, IF/ICC, ELISA - P31930

Core Product Specifications and Parameters

Biological Background: UQCRC1 Function and Localization

• UQCRC1, also known as Cytochrome b-c1 complex subunit 1, mitochondrial, or Core protein I, is a component of the ubiquinol-cytochrome c oxidoreductase (complex III) in the mitochondrial respiratory chain.
• It participates in electron transfer from ubiquinol to cytochrome c, coupling this reaction to proton translocation across the mitochondrial inner membrane, which drives ATP synthesis.
• UQCRC1 and UQCRC2 are homologous to the mitochondrial-processing peptidase (MPP) subunits; UQCRC1 may retain MPP activity and is potentially involved in processing UQCRFS1 into the mature Rieske protein.
• Subcellular localization is the mitochondrial inner membrane.
• Tissue expression includes brain (substantia nigra, striatum, cortex, cerebellum), spinal cord, heart, kidney, liver, and muscle.
• Post-translational modifications include acetylation and phosphorylation.
• Genetic variants of UQCRC1 have been linked to neuropathy and Parkinsonism.
• UQCRC1 seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons, with implications for Parkinson's disease (PubMed:33141179). Related references: PMID:33141179
• The computed molecular weight from sequence is ~52.6 kDa; the antibody detects a band at approximately 53 kDa in Western blotting.

Experimental Guidance and Technical Tips

• The immunogen was designed using a recombinant fusion protein spanning amino acids 156-480 of human UQCRC1; consider this antigen region when assessing epitope specificity.
• This antibody is suitable for applications including WB, IHC-P, IF/ICC, and ELISA; validate conditions in your specific sample matrix for optimal results.
• Reported cross-reactivity includes human, mouse, and rat; confirm in the relevant species model before use.
• As UQCRC1 is a mitochondrial inner membrane protein, consider using appropriate lysis and sample preparation methods to ensure proper solubilization and detection.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive partner for IVD raw material sourcing, supporting diagnostic developers and research laboratories from early-stage development to clinical application. This anti-UQCRC1 polyclonal antibody enables investigation of mitochondrial complex III function and related disease mechanisms. We offer a broad portfolio of validated antibodies, bulk ancillary reagents, and custom sourcing capabilities for rare targets, helping accelerate your diagnostic and research workflows.