Anti-UPB1 Rabbit Polyclonal Antibody for WB, ELISA - Q9UBR1

Core Product Specifications and Parameters

Biological Background: UPB1 Function and Localization

• UPB1 (beta-ureidopropionase), also known as BUP-1 or beta-alanine synthase, is a key enzyme in the pyrimidine degradation pathway.
• It catalyzes a late step in pyrimidine degradation by converting N-carbamoyl-beta-alanine into beta-alanine, ammonia, and carbon dioxide (PubMed:22525402, PubMed:24526388). Related references: PMID:22525402 PMID:24526388
• Similarly, it converts N-carbamoyl-beta-aminoisobutyrate into beta-aminoisobutyrate, ammonia, and carbon dioxide (PubMed:10415095, PubMed:10542323, PubMed:11508704). Related references: PMID:10415095 PMID:10542323 PMID:11508704
• UPB1 is a cytoplasmic enzyme, primarily detected in liver tissue at the protein level.
• The protein belongs to the hydrolase family and features a known 3D-structure; disease-associated variants have been reported.
• UPB1 undergoes phosphorylation, as identified by proteomics, suggesting post-translational regulation.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa1-240) of human UPB1; antibody binding may target epitopes within this region.
• For Western blotting (WB), use liver tissue lysates or cell lines expressing UPB1; expect a band around 43 kDa.
• Validate cross-reactivity with mouse and rat samples if the experimental design requires non-human models.
• For ELISA, consider using recombinant UPB1 protein as a standard to ensure specificity and quantitative accuracy.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a one-stop sourcing platform for IVD raw materials, including this anti-UPB1 polyclonal antibody, which supports research into pyrimidine metabolism and related disorders. Beyond validated antibodies, we supply optimized monoclonal/polyclonal pairs, bulk ancillary reagents, and customized sourcing for rare targets to assist your diagnostic development from concept to clinic.