Anti-UNC93B1 Polyclonal Antibody for WB, ELISA - Q9H1C4

Core Product Specifications and Parameters

Biological Background: UNC93B1 Function and Localization

• UNC93B1 (Protein unc-93 homolog B1) is a multi‑pass transmembrane protein that acts as a critical regulator of nucleotide‑sensing Toll‑like receptor (TLR) trafficking and signaling.
• It is essential for the transport of TLR3, TLR7, and TLR9 from the endoplasmic reticulum to endolysosomes, where they recognize pathogen‑derived nucleic acids and initiate innate immune cascades.
• UNC93B1 contributes to both innate and adaptive immunity and may play a role in autoreactive B‑cell removal, linking it to autoimmune regulation.
• The protein localizes primarily to the endoplasmic reticulum membrane, endosomes, lysosomes, and cytoplasmic vesicles such as phagosomes.
• UNC93B1 is highly expressed in antigen‑presenting cells, particularly plasmacytoid dendritic cells; high expression is also found in heart, with lower levels in kidney and other tissues.
• Post‑translational modifications include glycosylation and phosphorylation; it is classified under keywords such as Adaptive immunity, Antiviral defense, Glycoprotein, Transmembrane helix, and 3D‑structure.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a cytoplasmic domain peptide (residues 450‑550), which is likely accessible under denaturing conditions, making it suitable for WB. For ELISA, consider using peptide‑coated plates or full‑length recombinant protein.
• When working with mouse or rat samples, verify the sequence homology of the immunogen region in the target species to confirm expected cross‑reactivity.
• As a polyclonal antibody, slight lot‑to‑lot variation may occur; it is advisable to validate performance in your specific sample system and application.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio simplifies IVD raw‑material sourcing for diagnostic manufacturers and research labs working on innate immunity and TLR biology. Beyond this UNC93B1 antibody, we supply validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents, complemented by technical consulting for assay development. Contact us for rare target sourcing and customized support from concept to clinic.