Anti-UNC50 Rabbit Polyclonal Antibody for WB, ELISA - Q53HI1

Core Product Specifications and Parameters

Biological Background: UNC50 Function and Localization

• Protein unc-50 homolog, also known as periodontal ligament-specific protein 22 (PDLs22), GMH1 homolog, and uncoordinated-like protein, is encoded by the UNC50 gene (UNCL).
• UNC50 is involved in the cell surface expression of neuronal nicotinic receptors, facilitating receptor trafficking or stability (By similarity).
• The protein has RNA-binding activity, suggesting a potential role in post-transcriptional regulation (By similarity).
• It localizes to the inner nuclear membrane and the Golgi apparatus membrane, indicating a role in intracellular trafficking between these compartments.
• Tissue specificity: UNC50 is present in periodontal ligament fibroblasts at the protein level.
• Post-translational modifications include acetylation and phosphorylation, which may regulate its function or localization.
• UNC50 contains transmembrane domains, classifying it as a multi-pass membrane protein.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1-100) of human UNC50; consider using this antibody for detecting full-length UNC50 by Western blot.
• For WB, validate in the relevant sample system, such as cell lines expressing UNC50 or periodontal ligament fibroblasts.
• ELISA may be suitable for detecting UNC50 peptides or recombinant protein; optimize coating conditions and antibody concentration.
• Species cross-reactivity with mouse and rat suggests sequence conservation in the immunogen region; verify reactivity in your model system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one‑stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. For your UNC50-related neuroscience and cellular trafficking studies, we offer validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and custom sourcing for rare targets. Let CamelBio streamline your raw material procurement and accelerate your diagnostic development.