Anti-UGDH Rabbit Polyclonal Antibody for WB and ELISA - O60701

Core Product Specifications and Parameters

Biological Background: UGDH Function and Localization

• Catalyzes the formation of UDP-alpha-D-glucuronate, a crucial precursor for glycosaminoglycan biosynthesis. Related references: PMID:21502315 PMID:21961565 PMID:22123821

• Essential for the production of chondroitin sulfate and heparan sulfate, major components of the extracellular matrix. Related references: PMID:21502315 PMID:21961565 PMID:22123821

• Required for embryonic development and proper brain/neuronal development; mutations are associated with developmental and epileptic encephalopathy. Related references: PMID:32001716

• Widely expressed, detected in tissues including heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine, and colon. Related references: PMID:9737970

• Regulated by acetylation and phosphorylation; exists in multiple isoforms via alternative splicing.

• Functions as an allosteric enzyme and oxidoreductase, utilizing NAD as a cofactor.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 165-494 of human UGDH. Consider this region when designing assays to assess specificity.
• This antibody is suitable for Western blot (predicted molecular weight ~55 kDa) and ELISA. Validate in your specific sample system with appropriate controls.
• Confirmed cross-reactivity with human and mouse; for other species, verify sequence homology of the immunogen region.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers comprehensive IVD raw-material sourcing, including validated antibody pairs, monoclonal/polyclonal antibodies, and bulk ancillary reagents. Our portfolio features rare-target products like UGDH antibodies to support glycosaminoglycan biosynthesis research. Reach out for customized procurement solutions and technical support from concept to clinic.