Anti-UBTF Rabbit Polyclonal Antibody for WB, ELISA - P17480

Core Product Specifications and Parameters

Biological Background: UBTF Function and Localization

• UBTF, also known as upstream-binding factor 1 (UBF-1) and autoantigen NOR-90, is a nucleolar transcription factor that regulates ribosomal RNA (rRNA) gene expression.
• It specifically binds to the upstream control element of the rRNA gene promoter and, in cooperation with the SL1/TIF-IB complex, activates RNA polymerase I (Pol I) transcription and facilitates promoter escape.
• UBTF is predominantly localized to the nucleolus and nucleus.
• The protein undergoes alternative splicing and is subject to post-translational modifications including acetylation and phosphorylation, which may regulate its activity.
• Mutations in UBTF have been associated with disease variants linked to intellectual disability and neurodegeneration.

Experimental Guidance and Technical Tips

• When performing Western blot, a band at approximately 89 kDa may be expected. Validate in your specific sample system and choose appropriate loading controls.
• For ELISA, consider coating with the immunogen or native protein; optimize assay conditions for best signal-to-noise ratio.
• Based on cross-reactivity data, this antibody may detect UBTF in human, mouse, and rat samples, but always verify in your experimental model.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. For your UBTF research needs, we offer reliable antibody reagents suitable for immunoassay development in the areas of nucleolar function and ribosome biogenesis. Whether you require validated antibody pairs, optimized monoclonal or polyclonal antibodies, bulk ancillary reagents, or rare target raw-material sourcing, CamelBio is your trusted supply partner.