Anti-UBIAD1 Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - Q9Y5Z9

Core Product Specifications and Parameters

Biological Background: UBIAD1 Function and Localization

• UBIAD1 (UbiA prenyltransferase domain‑containing protein 1), also known as transitional epithelial response protein 1 (TERE1) or SCCD, is a member of the UbiA prenyltransferase family.
• It mediates menaquinone‑4 (MK‑4) biosynthesis by cleaving the side chain of phylloquinone and prenylating the naphthoquinone core with geranylgeranyl pyrophosphate, a process essential for endothelial cell development. Related references: PMID:20953171
• UBIAD1 is required for coenzyme Q10 (ubiquinone) synthesis in the Golgi membrane, protecting cardiovascular tissues from NOS3/eNOS‑dependent oxidative stress. Related references: PMID:23374346
• The protein localizes to the membranes of the endoplasmic reticulum, Golgi apparatus, and mitochondria, and is also found in the cytoplasm and nucleus.
• UBIAD1 is ubiquitously expressed across human tissues.
• The protein undergoes acetylation and alternative splicing; mutations are associated with corneal dystrophy.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N‑terminal region (amino acids 1–100) of human UBIAD1; verify its specificity in your sample system using appropriate controls.
• For western blotting, the predicted molecular weight is 37 kDa; consider optimizing primary antibody dilution and use a loading control for normalization.
• When performing IHC‑P, evaluate antigen retrieval conditions and include positive tissue controls (e.g., kidney, brain, or pancreas, where MK‑4 is abundant).
• This antibody cross‑reacts with human, mouse, and rat; validate performance in the species of interest before large‑scale experiments.

CamelBio: Your One‑Stop Sourcing Bridge

CamelBio supports IVD manufacturers and research teams with a comprehensive portfolio of validated raw materials, including monoclonal and polyclonal antibodies, antigen‑matched pairs, and bulk ancillary reagents. This anti‑UBIAD1 polyclonal antibody is part of our offering for studies focused on vitamin K metabolism, coenzyme Q10 biology, and cardiovascular development. Whether you need rare‑target sourcing or complete workflow solutions, CamelBio bridges your project from concept to clinic.