Anti-UBE2Z Rabbit Polyclonal Antibody for WB, ELISA - Q9H832

Core Product Specifications and Parameters

Biological Background: UBE2Z Function and Localization

• UBE2Z, also known as USE1 or HOYS7, is a ubiquitin-conjugating enzyme E2 Z that mediates the covalent attachment of ubiquitin to target proteins.
• It functions specifically with the E1 enzyme UBA6, rather than the canonical UBE1, to charge ubiquitin.
• UBE2Z may play a role in apoptosis regulation, though the exact mechanism remains to be fully characterized.
• The protein localizes to both the cytoplasm and nucleus, suggesting involvement in diverse cellular processes.
• It is widely expressed across tissues, with highest levels observed in placenta, pancreas, spleen, and testis.
• Post-translational modifications include phosphorylation (as indicated by the keywords), and the gene undergoes alternative splicing, potentially generating multiple isoforms.
• Keywords include transferase activity, Ubl conjugation pathway, and apoptosis, highlighting its enzymatic role in ubiquitin-like modifications.

Experimental Guidance and Technical Tips

• The immunogen used corresponds to amino acids 115–354 of human UBE2Z, covering a substantial portion of the protein. For Western blot, the expected band is approximately 38 kDa; consider using appropriate positive control lysates (e.g., human or mouse cell lines expressing UBE2Z).
• This antibody has been tested for WB and ELISA; it may also be suitable for other applications, but optimization and validation in the relevant sample systems are recommended.
• Cross-reactivity with mouse is confirmed, enabling broader experimental design across species.

CamelBio: Your One-Stop Sourcing Bridge

• CamelBio serves as your comprehensive one-stop sourcing partner for IVD raw materials, offering validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents to support ubiquitin pathway and apoptosis research.
• Whether you need this anti-UBE2Z antibody or seek rare target raw-material sourcing, our global supply network ensures reliable access to high-quality immunoreagents tailored for diagnostic development.