Anti-UBASH3B Polyclonal Antibody for WB, IHC-P, IF/ICC, ELISA - Q8TF42

Core Product Specifications and Parameters

Biological Background: UBASH3B Function and Localization

• UBASH3B (Ubiquitin-associated and SH3 domain-containing protein B), also designated STS-1, TULA-2, or p70, is a member of the TULA family of protein phosphatases.
• It interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases, thereby promoting accumulation of activated target receptors on the cell surface.
• Known target receptors include T-cell receptors (TCR) and epidermal growth factor receptor (EGFR).
• Exhibits tyrosine phosphatase activity toward several substrates, including EGFR, FAK, SYK, and ZAP70.
• Functions to down-regulate proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
• Localizes to both the cytoplasm and nucleus.
• Contains an SH3 domain and is classified as a hydrolase and phosphoprotein.

Experimental Guidance and Technical Tips

• The immunogen comprises the N-terminal region (amino acids 1–300) of human UBASH3B, which includes the SH3 domain; this region may contribute to recognition of full-length protein in western blotting (predicted band ~73 kDa).
• This antibody is indicated for WB, IHC-P, IF/ICC, and ELISA applications; consider optimizing dilutions and detection conditions for each specific assay.
• Cross-reactivity has been observed with human, mouse, and rat samples; validate performance in the target species and tissue before use in critical experiments.
• As UBASH3B is expressed in both cytoplasmic and nuclear compartments, signal localization should be carefully evaluated in imaging applications.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. For immunology and cell signaling research, we supply validated antibody pairs, optimized polyclonal antibodies like this anti-UBASH3B, bulk ancillary reagents, and rare target raw-material sourcing. Whether you need off-the-shelf solutions or custom development for your assay pipeline, CamelBio bridges the gap between discovery and diagnostic application.