Anti-TYMP Polyclonal Antibody for WB and ELISA - P19971

Core Product Specifications and Parameters

Biological Background: TYMP Function and Localization

• TYMP encodes thymidine phosphorylase, also known as platelet-derived endothelial cell growth factor (PD-ECGF), gliostatin, or TdRPase.
• The protein catalyzes the reversible phosphorolysis of thymidine, generating thymine and 2-deoxy-D-ribose 1-phosphate, which are utilized in nucleotide salvage pathways.
• It exhibits angiogenic activity by promoting endothelial cell proliferation and migration, and also acts as a chemotactic factor for endothelial cells in vitro.
• Multiple isoforms are produced through alternative splicing.
• Post-translational modifications include phosphorylation (phosphoprotein), and the enzyme belongs to the glycosyltransferase/transferase class.
• Clinical associations encompass disease variants linked to mitochondrial neurogastrointestinal encephalopathy (MNGIE), primary mitochondrial disease, and progressive external ophthalmoplegia.

Experimental Guidance and Technical Tips

• The immunogen spans nearly the full-length protein (aa 11–482), likely eliciting antibodies that recognize multiple epitopes; consider epitope mapping if precise binding regions are required.
• For western blot, a band of approximately 50 kDa is expected; validate expression in human and rat cell lysates or tissue extracts.
• In ELISA protocols, the antibody may serve as a capture or detection reagent; optimize coating concentrations and cross-reactivity checks with related proteins.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a streamlined procurement channel for IVD raw materials, connecting you with validated antibodies like this anti-TYMP polyclonal for angiogenesis and nucleoside metabolism research. Whether you need optimized monoclonal/polyclonal pairs, bulk ancillary reagents, or rare-target sourcing, CamelBio supports your entire development pipeline—from concept to clinic.