Anti-TXNL1 Polyclonal Antibody for WB, IHC-P, IF/ICC, ELISA - O43396

Core Product Specifications and Parameters

Biological Background: TXNL1 Function and Localization

• TXNL1 encodes thioredoxin-like protein 1 (32 kDa thioredoxin-related protein, TRP32), a member of the thioredoxin family containing a conserved redox-active center.
• It functions as an active thioredoxin with a redox potential of about -250 mV, enabling disulfide reduction and electron transport roles.
• Subcellularly, TXNL1 distributes to both the cytoplasm and nucleus, consistent with functions in antioxidant defense and redox signaling.
• Expression of TXNL1 is ubiquitous across tissues, suggesting a fundamental housekeeping role in cellular redox homeostasis.
• The protein is subject to phosphorylation, potentially regulating its activity or interactions.
• Key structural features include a disulfide bond within the redox-active site, and it has been identified in proteasome complexes, hinting at involvement in redox-regulated degradation processes.

Experimental Guidance and Technical Tips

• The immunogen consists of full-length recombinant human TXNL1 (aa 1-289); the resulting rabbit polyclonal serum likely recognizes multiple native epitopes.
• For Western blot, expect a band near 32 kDa; use appropriate reducing conditions to resolve redox-dependent shifts.
• In immunohistochemistry (IHC-P) and immunofluorescence (IF/ICC), validate the antibody in known TXNL1-expressing tissues/cells and include appropriate controls.
• Cross-reactivity with mouse and rat TXNL1 is indicated; when testing additional species, check sequence homology to predict reactivity.
• As with all polyclonal preparations, evaluate lot-to-lot consistency for critical applications and consider titration for optimal signal-to-noise.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides researchers and diagnostic developers with streamlined access to IVD raw materials, including this TXNL1 polyclonal antibody for redox biology and proteostasis studies. Beyond single reagents, we offer validated antibody pairs, optimized monoclonals/polyclonals, bulk ancillary reagents, and rare-target sourcing—bridging the gap from concept to clinical assay development.