Anti-TXNIP Polyclonal Antibody for WB, ELISA - Q9H3M7

Core Product Specifications and Parameters

Biological Background: TXNIP Function and Localization

• Thioredoxin-interacting protein (TXNIP), also known as VDUP1, is a stress-responsive protein that may act as an oxidative stress mediator by inhibiting thioredoxin activity or limiting its bioavailability. Related references: PMID:17603038
• TXNIP functions as a transcriptional repressor, possibly serving as a bridge between transcription factors and corepressor complexes, and its overexpression induces G0/G1 cell cycle arrest. Related references: PMID:12821938
• Acts as a tumor suppressor by inhibiting tumor cell growth. Related references: PMID:18541147
• Inhibits proteasomal degradation of DDIT4, thereby contributing to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Related references: PMID:21460850
• Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the translocation of CDKN1B from the nucleus to the cytoplasm; also required for the maturation of natural killer cells (By similarity).
• Subcellularly, TXNIP localizes to both the cytoplasm and nucleus.
• Undergoes alternative splicing and is subject to post-translational modifications including phosphorylation, disulfide bond formation, and ubiquitination.
• The calculated molecular weight of human TXNIP is approximately 44 kDa.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a synthetic peptide from amino acids 291–391 of human TXNIP; this C‑terminal region may exhibit sequence conservation with mouse and rat, potentially contributing to the observed cross‑reactivity.
• For Western blotting, consider testing a dilution range of 1:500–1:2000 and validate the signal in a biologically relevant sample system that expresses TXNIP.
• In ELISA, the peptide immunogen can serve as a positive control to evaluate antibody binding under defined conditions; empirical optimization of coating and detection parameters is advised.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with a streamlined, single‑stop solution for IVD raw‑material procurement, including validated antibody pairs, optimized polyclonal antibodies such as this anti‑TXNIP reagent, and ancillary reagents in bulk. Whether your TXNIP‑related projects require consistent supply for assay development or access to rare‑target antibodies, our integrated sourcing network supports you from concept to clinic. Partner with CamelBio to secure high‑quality materials and accelerate your diagnostic innovation.