Anti-TRPV3 Polyclonal Antibody for WB, ELISA - Q8NET8

Core Product Specifications and Parameters

Biological Background: TRPV3 Function and Localization

• TRPV3 encodes a non-selective, calcium-permeant cation channel activated by innocuous warm temperatures and shows an increased response at noxious temperatures above 39°C (PubMed:12077604, PubMed:12077606, PubMed:26818531). Related references: PMID:12077604 PMID:12077606 PMID:26818531
• Channel activation exhibits outward rectification and the pore can dilate to allow permeability to larger cations (PubMed:12077604, PubMed:37648856). Related references: PMID:12077604 PMID:37648856
• TRPV3 may associate with TRPV1 and modulate its activity (PubMed:12077606). Related references: PMID:12077606
• TRPV3 is a negative regulator of hair growth and cycling; its signaling suppresses keratinocyte proliferation and induces apoptosis and premature catagen entry (PubMed:21593771). Related references: PMID:21593771
• Subcellular localization includes the cell membrane, cytoplasm, and lysosome.
• Abundantly expressed in the central nervous system; widely expressed at low levels; detected in dorsal root ganglia and in keratinocyte layers of hair follicles.
• Keywords highlight alternative splicing, ANK repeats, calcium channel/transport, involvement in palmoplantar keratoderma, and disease variant associations.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a synthetic peptide within amino acids 400–500 of human TRPV3; consider sequence alignment with mouse TRPV3 to evaluate cross-reactivity.
• For Western blot, expect a band around 91 kDa; validate detection in the relevant sample system and consider using a blocking peptide to confirm specificity.
• In ELISA, test against the immunogen peptide or recombinant TRPV3 protein, and include appropriate positive and negative controls.
• Mouse cross-reactivity is reported; if working with mouse tissues, verify performance and optimize blocking conditions accordingly.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a one-stop sourcing partner for IVD raw materials, supporting diagnostic manufacturers and research groups with validated antibodies, optimized antibody pairs, and bulk ancillary reagents. Our supply capabilities encompass the TRPV3 target, which is central to thermosensation, ion channel physiology, and dermatological research. For rare or emerging targets, CamelBio also assists with custom antibody development and raw-material sourcing, ensuring a seamless pathway from concept to clinical application.