Anti-TRPC1 Rabbit Monoclonal Antibody for WB, ELISA - P48995

Core Product Specifications and Parameters

Biological Background: TRPC1 Function and Localization

• TRPC1 (Transient receptor potential channel 1), also known as TRP-1, is a member of the transient receptor potential (TRP) ion channel family.
• It forms a receptor-activated, non-selective calcium-permeable cation channel, and can also be activated by intracellular calcium store depletion. Related references: PMID:11139478 PMID:15016832 PMID:39478185
• TRPC1 can assemble into heteromeric channels with TRPC4 or TRPC5, which exhibit reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel. Related references: PMID:39478185
• The channel is also permeable to monovalent ions such as sodium, lithium, and cesium. Related references: PMID:39478185
• TRPC1 is ubiquitously expressed in human tissues and localizes to the cell membrane.
• The protein contains multiple ankyrin repeats, transmembrane helices, and undergoes post-translational modifications including phosphorylation, disulfide bond formation, and zinc binding.
• Alternative splicing generates multiple isoforms of TRPC1.

Experimental Guidance and Technical Tips

• The immunogen used to generate this antibody is a synthetic peptide spanning amino acids 400–500 of human TRPC1, targeting an intracellular region. Consider this when designing epitope-specific detection strategies.
• For Western blotting, the predicted molecular weight of TRPC1 is 88–91 kDa. Validate the observed band size in appropriate positive control lysates.
• In ELISA applications, confirm optimal antibody dilution and coating conditions using recombinant TRPC1 protein or cell lysates expressing the target.
• Cross-reactivity with mouse and rat TRPC1 has been observed; however, always verify specificity in your experimental system with appropriate controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your integrated partner for IVD raw-material sourcing, offering validated monoclonal and polyclonal antibodies, optimized antibody pairs, ancillary bulk reagents, and rare target materials for every stage of diagnostic and research development. Whether you are investigating ion channel biology, calcium signaling, or developing immunoassays for TRPC1-related applications, we bridge the gap from concept to clinic with reliable supply solutions.