Anti-Tropomodulin-2 (TMOD2) Rabbit Monoclonal Antibody for WB, IF-P, IHC-P, ELISA - Q9NZR1

Core Product Specifications and Parameters

Biological Background: TMOD2 Function and Localization

• TMOD2 (Tropomodulin-2) is a neuronal-specific isoform of the tropomodulin family, also known as N-Tmod.
• It functions as an actin capping protein that blocks elongation and depolymerization at the pointed ends of actin filaments.
• In complex with tropomyosin (Tmod/TM), it contributes to the formation of short actin protofilaments, defining the geometry of the membrane skeleton.
• Localizes to the cytoplasm and associates with the cytoskeleton.
• Exhibits neuronal tissue-specific expression, consistent with its roles in synaptic morphology and neuronal architecture.
• Undergoes alternative splicing, generating multiple isoforms with potentially distinct activities.
• Is subject to phosphorylation and has been identified by direct protein sequencing and proteomics screens, underscoring its dynamic regulation.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide from the N-terminal region; epitope is likely within the first 100 amino acids.
• For Western blot, the expected band is ~40 kDa; consider validating in neuronal tissue lysates or cell lines.
• For immunofluorescence (IF) and immunohistochemistry (IHC), fixation/permeabilization conditions should be optimized for cytoskeletal targets.
• Cross-reactivity with mouse and rat is reported, enabling translational studies in rodent models of neurobiology.
• As a rabbit monoclonal antibody, it offers consistent lot-to-lot reproducibility for quantitative applications like ELISA.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio empowers diagnostic manufacturers and researchers with reliable access to high-quality IVD raw materials, including this anti-TMOD2 rabbit monoclonal antibody ideal for studying neuronal cytoskeletal dynamics. Beyond single antibodies, we offer validated antibody pairs, bulk ancillary reagents, and sourcing for rare and emerging targets to streamline your assay development from concept to clinic.