Anti-TROP-2 Rabbit Polyclonal Antibody for IF-P and ELISA - Q8BGV3

Core Product Specifications and Parameters

Biological Background: TROP-2 Function and Localization

• TROP-2 (Tacstd2) is a cell surface glycoprotein, also termed tumor-associated calcium signal transducer 2 or Trop-2.
• It may function as a growth factor receptor, potentially mediating intracellular calcium signals.
• Subcellular localization is at the membrane, featuring a signal peptide, an extracellular domain, a single transmembrane helix, and a short cytoplasmic tail.
• Post-translational modifications include N-linked glycosylation and disulfide bond formation, as indicated by UniProt keywords.
• Tissue expression is observed in kidney, lung, ovary, and testis, with particularly high levels in immortalized keratinocytes.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 25–270, which covers nearly the entire extracellular region; this suggests the antibody may recognize the native protein in cell surface immunofluorescence (IF-P).
• For ELISA applications, consider using recombinant mouse TROP-2 protein as a positive control and standard.
• Validate antibody specificity in relevant mouse tissue samples or cell lines known to express Trop-2, such as keratinocyte-derived or tumor lines.
• Due to the polyclonal nature, multiple epitopes may be targeted, potentially enhancing signal but also necessitating careful titration to minimize background.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive partner for IVD raw-material sourcing, offering this anti-TROP-2 polyclonal antibody alongside validated antibody pairs, optimized monoclonal/polyclonal reagents, and bulk ancillary supplies. Whether your focus is on tumor biology, cell surface markers, or growth factor receptor research, we streamline procurement from concept to clinic—including custom sourcing for rare and emerging targets.