Anti-TROP-2 Monoclonal Antibody for Flow Cytometry - P09758

Core Product Specifications and Parameters

Biological Background: Tumor-associated Calcium Signal Transducer 2 (TROP-2) Function and Localization

• Tumor-associated calcium signal transducer 2 (TROP-2), encoded by the TACSTD2 gene, is a cell surface glycoprotein also known as GA733-1, EGP-1, and M1S1.
• Predicted to function as a growth factor receptor, potentially mediating signaling pathways involved in cell proliferation and survival.
• Localized to the plasma membrane, consistent with a role in extracellular signal transduction.
• Tissue expression is notably high in placenta and pancreatic carcinoma cell lines, highlighting its relevance in both normal development and tumor biology.
• Classified as a tumor antigen, making it a candidate for targeted cancer immunotherapies and diagnostic markers.
• Structural features include a single transmembrane helix, disulfide bonds, and N-linked glycosylation, which are critical for its stability and interactions.

Experimental Guidance and Technical Tips

• For flow cytometry, consider using cell lines known to express TROP-2, such as human placental or pancreatic carcinoma cells (e.g., BxPC-3, PANC-1), and validate in a negative control line.
• Since the antibody is directly conjugated to , no secondary antibody is required; however, titrate the antibody to determine the optimal concentration for your specific experimental conditions.
• Including a viability dye can help exclude dead cells and improve data quality in FC assays targeting membrane proteins.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with one-stop access to IVD raw materials, technical services, and consulting. For TROP-2, a well-established tumor antigen, we can support your assay development with validated antibody pairs, optimized monoclonal antibodies, and bulk ancillary reagents. Whether you need routine materials or rare-target sourcing, CamelBio bridges concept to clinic with reliable B2B supply solutions.