Anti-TrKC Polyclonal Antibody for WB, ELISA - Q16288

Core Product Specifications and Parameters

Biological Background: TrKC (NT-3 Growth Factor Receptor) Function and Localization

• TrkC, encoded by NTRK3, is a member of the neurotrophin receptor tyrosine kinase family and is often referred to as GP145-TrkC or TrkC tyrosine kinase.
• Ligand binding by neurotrophin-3 (NTF3) triggers receptor autophosphorylation, activating downstream PI3K/AKT and MAPK signaling cascades that regulate cell survival and differentiation.
• The receptor localizes to the cell membrane and is essential for proper nervous system and cardiac development.
• Isoform 2 shows tissue‑specific regulation, with higher expression in adult brain than fetal brain, indicating a role in mature neuronal functions.
• Structural features include immunoglobulin‑like domains, leucine‑rich repeats, and a tyrosine kinase domain; the protein is annotated as a glycoprotein, phosphoprotein, and contains conserved disulfide bonds.

Experimental Guidance and Technical Tips

• The immunogen targets the extracellular region (aa 40–300), which may allow detection of both full‑length and certain truncated TrkC isoforms; validate specificity in your target tissue or cell line.
• For Western blotting, consider that glycosylation can shift the apparent molecular weight above the predicted 94 kDa; inclusion of positive controls from neuronal tissue and molecular weight markers is recommended.
• Cross‑reactivity with mouse and rat suggests utility in rodent models, but confirm species‑specific reactivity before designing experiments.
• As a polyclonal antibody, lot‑to‑lot consistency should be monitored if used in quantitative immunoassays; optimal working dilutions should be determined empirically.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as your integrated procurement partner for IVD raw materials, offering a comprehensive portfolio from optimized antibodies to ancillary reagents. This TrkC polyclonal antibody is available in bulk and can be paired with matched detection systems to support neurotrophin signaling research and diagnostic assay development. Whether you need validated antibody pairs, recombinant proteins, or rare‑target raw‑material sourcing, CamelBio bridges your concept‑to‑clinic journey.