Anti-TRIM41 Polyclonal Antibody for WB and ELISA - Q8WV44

Core Product Specifications and Parameters

Biological Background: TRIM41 Function and Localization

• E3 ubiquitin-protein ligase TRIM41 (also known as RINCK) is a member of the tripartite motif (TRIM) family, characterized by a RING finger domain, B-box, and coiled-coil regions.
• Functions as an E3 ligase essential for innate antiviral response by directly targeting influenza A virus and vesicular stomatitis virus nucleoproteins for ubiquitination and proteasomal degradation, thereby limiting viral infections. Related references: PMID:28169297, PMID:29899090, PMID:31979016
• Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS. Related references: PMID:29760876
• Mediates 'Lys-63'-linked polyubiquitylation of BCL10, which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity).
• Catalyzes ubiquitin-mediated degradation of various substrates including protein kinase C, ZSCAN21, and TOP3B, suggesting roles beyond immune response. Related references: PMID:17893151, PMID:33378676
• Localizes to both the cytoplasm and nucleus.
• Expressed in multiple tissues with highest levels in heart and skeletal muscle.
• Contains a RING-type zinc finger and is classified under phosphoprotein, transferase, and Ubl conjugation pathway keywords; undergoes alternative splicing.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 421-630 of human TRIM41; for Western blotting, consider using appropriate loading controls and validating the band size (predicted ~72 kDa) in the relevant sample system.
• As a polyclonal antibody, it may recognize multiple epitopes, which can enhance detection sensitivity but may also increase background; optimize blocking and washing conditions.
• For ELISA applications, consider titrating the antibody and confirming specificity with recombinant protein or peptide competition assays.
• Cross-reactivity with mouse and rat is reported; perform species-specific validation if switching between model organisms.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research teams with streamlined access to high-quality IVD raw materials, including validated antibody pairs and optimized polyclonal antibodies like this anti-TRIM41 product. Our comprehensive portfolio covers innate immunity and ubiquitination research targets, supported by bulk ancillary reagents and rare target sourcing capabilities. Partner with CamelBio to accelerate your assay development from concept to clinic with reliable, one-stop procurement solutions.