Anti-TRAPPC6B Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - Q86SZ2

Core Product Specifications and Parameters

Biological Background: TRAPPC6B Function and Localization

• TRAPPC6B is a component of the TRAPP tethering complex, essential for vesicle trafficking from the ER to the Golgi and between Golgi cisternae. Related references: PMID:16025134, PMID:16828797
• In the developing nervous system, TRAPPC6B modulates intracellular calcium oscillations that are critical for proper neuronal differentiation, migration, and circuit formation.
• The protein resides on the cis-Golgi network and endoplasmic reticulum, consistent with its function in early secretion.
• TRAPPC6B is broadly expressed across tissues, with notable enrichment in the fetal and adult brain, highlighting its role in neurodevelopment.
• Mutations in TRAPPC6B have been linked to neurodevelopmental pathologies such as intellectual disability and epilepsy, underscoring its clinical significance.

Experimental Guidance and Technical Tips

• For Western blot (WB), target detection is expected at approximately 18 kDa; we recommend titrating the antibody and including appropriate positive and negative controls.
• In immunohistochemistry (IHC-P), antigen retrieval conditions (e.g., citrate buffer, pH 6.0) should be optimized; test on FFPE sections from brain or other relevant tissues.
• ELISA applications can be developed using the recombinant immunogen as a coating standard; consider a sandwich format if paired with a capture antibody.
• The antibody is reported to react with mouse and rat TRAPPC6B; confirm cross-reactivity in your model system, as sequence homology may affect affinity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic and research communities by consolidating validated raw materials for assay development. In the field of neural development and membrane trafficking, we provide high-quality antibodies like this anti-TRAPPC6B pAb, and can source complementary reagents including recombinant proteins, secondary antibodies, and ELISA kits. For customized bulk orders or rare-target material procurement, our supply chain network ensures timely delivery from concept to clinic.