Anti-TRAPPC2 (SEDL) Rabbit Polyclonal Antibody for WB, ELISA - P0DI81

Core Product Specifications and Parameters

Biological Background: TRAPPC2 Function and Localization

• TRAPPC2 (also known as Sedlin) is a subunit of the TRAPP (trafficking protein particle) complex that mediates vesicular tethering and ER-to-Golgi transport.
• It may prevent transcriptional repression and induction of cell death by interacting with ENO1 (alpha-enolase) (by similarity).
• The protein is broadly expressed in human tissues, including brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, and fibroblasts.
• Subcellularly, TRAPPC2 localizes to the cytoplasm, perinuclear region, ER-Golgi intermediate compartment, and nucleus.
• Annotated keywords indicate involvement in alternative splicing, and it is a phosphoprotein, suggesting regulation by post-translational modifications.
• Disease-associated variants are linked to spondyloepiphyseal dysplasia tarda (SEDT), a skeletal dysplasia.

Experimental Guidance and Technical Tips

• The immunogen corresponds to full-length human TRAPPC2 (residues 1–140), enabling recognition of endogenous TRAPPC2 in western blotting; consider using whole-cell lysates from human cell lines.
• Expected molecular weight is 16 kDa; validate against a suitable ladder in your gel system.
• For ELISA, the recombinant immunogen can serve as a positive control or coating antigen; titrate empirically for your assay conditions.
• No cross-reactivity data with other species are provided; if extending to non-human samples, validate reactivity experimentally.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research institutes with one-stop access to IVD raw materials, including validated antibodies, recombinant proteins, and ancillary reagents. This TRAPPC2 rabbit polyclonal antibody supports studies in intracellular trafficking and transcription regulation, and we can assist with sourcing related targets such as TRAPP complex subunits and transport markers. As your B2B partner, we focus on bridging procurement gaps—from optimized monoclonal and polyclonal antibodies to bulk raw materials for scale-up.