Anti-TRAF7 Polyclonal Antibody for WB, ELISA - Q6Q0C0

Core Product Specifications and Parameters

Biological Background: TRAF7 Function and Localization

• E3 ubiquitin and SUMO-protein ligase involved in innate immunity, inflammation, and apoptosis (PubMed:15001576, 37086853). Related references: PMID:15001576 PMID:37086853
• Potentiates MAP3K3-mediated activation of the JUN/AP1 and DDIT3 transcriptional regulators, modulating stress responses (PubMed:14743216). Related references: PMID:14743216
• Negatively regulates NF-kappa-B signaling by promoting 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA, targeting them for lysosomal degradation (PubMed:21518757). Related references: PMID:21518757
• Suppresses RLR-mediated antiviral innate immunity via 'Lys-48'-linked ubiquitination of TBK1 through its RING domain (PubMed:37086853). Related references: PMID:37086853
• Sequesters the transcriptional regulator MYB to the cytosol via SUMOylation, negatively regulating its activity (By similarity).
• Localizes to cytoplasmic vesicles, cytoplasm, and nucleus, enabling context-dependent signaling functions.
• Contains WD repeats and a RING-type zinc finger domain characteristic of E3 ligases, supporting protein interaction and ubiquitin transferase activity.
• Ubiquitously expressed with highest levels in skeletal muscle, heart, colon, spleen, kidney, liver, and placenta, reflecting broad regulatory roles.

Experimental Guidance and Technical Tips

• The antibody was raised against a recombinant immunogen corresponding to amino acids 260-400 of human TRAF7, an internal region that may detect full-length and relevant isoforms; consider verifying isoform specificity in your experimental system.
• For Western blotting, the predicted protein weight is approximately 75 kDa (specification); note that post-translational modifications or isoforms may cause shifts; optimize loading and detection conditions.
• This polyclonal antibody is suitable for ELISA; however, each application should be validated in the relevant sample matrix to ensure specificity and sensitivity.
• Ensure proper storage and handling as recommended for rabbit polyclonal antibodies (shipped on ice bag; store at -20°C or below upon receipt).

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with a streamlined sourcing platform for IVD raw materials. Our portfolio includes validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and support for rare target procurement—all tailored to accelerate development in areas such as innate immunity and inflammation, where TRAF7 is a key regulator. Contact us to explore how we can help bridge your research and diagnostic needs from concept to clinic.