Anti-TNFRSF17 Rabbit Polyclonal Antibody for WB, IF/ICC, ELISA - Q02223

Core Product Specifications and Parameters

Biological Background: TNFRSF17 Function and Localization

• Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), also known as B-cell maturation antigen (BCMA), BCM, CD269, or TNFRSF13A.
• Functions as a receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL, critically promoting B-cell survival and humoral immunity.
• Ligand binding activates downstream NF-kappa-B and JNK signaling pathways.
• Belongs to the tumor necrosis factor receptor superfamily.
• Subcellular localization includes the cell membrane and endomembrane system.
• Predominantly expressed in mature B-cells, with absence in T-cells and monocytes.
• Alternative splicing produces multiple isoforms; the protein contains a disulfide bond and a transmembrane domain.
• Classified as a proto-oncogene; involved in chromosomal rearrangements in some malignancies.

Experimental Guidance and Technical Tips

• The antibody is a rabbit polyclonal raised against an N-terminal peptide (aa 1-100); consider that it may detect multiple isoforms or cleaved fragments.
• For Western blotting, the predicted molecular weight is ~20 kDa; post-translational modifications may shift the observed band. Validate in appropriate B-cell lysates.
• In immunofluorescence/ICC, permeabilization may be needed for optimal detection of this membrane receptor.
• For ELISA applications, the antibody can be used as a capture or detection reagent; pairing with other antibodies may improve sensitivity.
• Cross-reactivity with mouse and rat is reported; verify reactivity in your specific sample system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive one-stop platform for IVD raw materials, connecting diagnostic manufacturers and researchers with high-quality antibodies like this anti-TNFRSF17 polyclonal for B-cell immunology studies. Our supply capabilities include validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target sourcing to support your entire development pipeline.