Anti-TNFRSF13C Rabbit Polyclonal Antibody for WB and ELISA - Q96RJ3

Core Product Specifications and Parameters

Biological Background: TNFRSF13C Function and Localization

• Tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) is also known as BAFF receptor (BAFF-R), CD268, or BLyS receptor 3.
• Acts as a B-cell-specific receptor for the cytokine TNFSF13B/BAFF/BLyS, promoting survival of mature B-cells and the B-cell response.
• Localized to the cell membrane via a signal-anchor, with a transmembrane helix and disulfide bond-containing extracellular domain.
• Highly expressed in secondary lymphoid organs (spleen, lymph node) and resting B-cells; lower expression in activated B-cells, CD4+ T-cells, thymus, and peripheral blood leukocytes.
• Alternative splicing generates multiple isoforms; mutations in TNFRSF13C are linked to common variable immunodeficiency (CVID4).
• Belongs to the tumor necrosis factor receptor superfamily, playing a key role in adaptive immunity.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal extracellular domain (aa 1–80) of human TNFRSF13C, which contains the ligand-binding region; this design may favor detection of the receptor in its native conformation.
• For WB, consider that the predicted molecular weight is approximately 19 kDa; validate with appropriate positive controls and note any potential post-translational modifications that may alter migration.
• Given the reported cross-reactivity with mouse, verify performance in mouse-derived samples and adjust conditions as needed.
• For ELISA, the polyclonal nature of the antibody may provide robust signal through recognition of multiple epitopes; pair with a suitable detection antibody and test with recombinant protein or native samples.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research institutions with streamlined access to quality-assured IVD raw materials, including validated antibody pairs, monoclonal and polyclonal antibodies, and bulk ancillary reagents. This anti-TNFRSF13C antibody supports immunoassay development for B-cell-related disorders and immune function studies. Our team assists in sourcing rare-target reagents and offers technical consultation to accelerate your project from concept to clinic.