Anti-TMPRSS11A Polyclonal Antibody for WB, ELISA - Q6ZMR5

Core Product Specifications and Parameters

Biological Background: TMPRSS11A Function and Localization

• TMPRSS11A, also known as airway trypsin-like protease 1, HATL1, ECRG1, and HESP, is a type-II transmembrane serine protease belonging to the TMPRSS family.
• It contains a serine protease domain and is predicted to function as a hydrolase, likely involved in proteolytic processing at the cell surface.
• Overexpression of TMPRSS11A inhibits cell growth and induces G1 cell cycle arrest, suggesting a role in cellular senescence.
• The protein is localized to the membrane, consistent with its transmembrane domain and signal-anchor sequence.
• TMPRSS11A is expressed in multiple tissues including esophagus, liver, colon, and lung; its expression is notably down-regulated in esophageal cancers.
• Post-translational modifications include glycosylation and disulfide bond formation, typical of secreted and membrane proteases.
• Alternative splicing may generate multiple isoforms, potentially impacting its function or localization.

Experimental Guidance and Technical Tips

• For Western blotting, a band around 47 kDa is expected; however, glycosylation may shift the apparent molecular weight. Consider using a relevant cell line or tissue lysate for verification.
• The polyclonal nature of this antibody may provide robust signal in ELISA; cross-adsorption can be considered to minimize background if needed.
• Since cross-reactivity is reported for human, mouse, and rat, this antibody can be utilized across these species with appropriate validation.
• For novel applications, optimization of dilution and incubation conditions is recommended; the immunogen region (aa 300–421) lies in the extracellular domain, favoring detection of full-length or cleaved forms.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This TMPRSS11A antibody is part of our growing catalog supporting senescence, cell cycle, and cancer research. In addition to validated antibody pairs and optimized monoclonal/polyclonal antibodies, we offer bulk ancillary reagents and can assist with sourcing rare-target raw materials to streamline your assay development and production.