Anti-TMPRSS11A Polyclonal Antibody for WB and ELISA - Q6ZMR5

Core Product Specifications and Parameters

Biological Background: TMPRSS11A Function and Localization

• Encoded by the TMPRSS11A (ECRG1, HATL1, HESP) gene, this protein is a putative serine protease that may function in cellular senescence by inhibiting cell growth and inducing G1 cell cycle arrest.
• Belongs to the type II transmembrane serine protease family, featuring a signal-anchor transmembrane domain that localizes the protein to the membrane.
• Expressed in esophagus, liver, colon, and lung, with expression reportedly down-regulated in esophageal cancers.
• Post-translational modifications include N-linked glycosylation and disulfide bond formation, typical of serine proteases.
• Multiple isoforms exist due to alternative splicing, which may modulate its proteolytic activity or subcellular distribution.
• Identified as a reference proteome component, with proteomics identification confirming its molecular weight of approximately 47 kDa.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 300-421, a region likely within the extracellular protease domain; thus, the antibody is expected to detect the full-length protein and potentially cleaved/processed forms.
• For WB, consider testing lysates from human esophagus, liver, colon, or lung tissues where TMPRSS11A is expressed; down-regulation in esophageal cancer cell lines may require careful validation.
• Cross-reactivity with mouse and rat indicates conserved epitope; however, verify species-specific expression patterns and molecular weight shifts in the relevant sample system.
• Since the antibody is polyclonal, we recommend titrating the optimal working dilution for each application and including appropriate controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive portfolio of IVD raw materials, including this validated anti-TMPRSS11A polyclonal antibody for your diagnostic and research workflows. As your one-stop sourcing bridge, we provide optimized antibody pairs, bulk ancillary reagents, and customized support for rare targets like TMPRSS11A, accelerating your projects from concept to clinic.