Anti-TMOD4 Rabbit Polyclonal Antibody for WB, ELISA - Q9NZQ9

Core Product Specifications and Parameters

Biological Background: TMOD4 Function and Localization

• TMOD4, also known as skeletal muscle tropomodulin (Sk-Tmod), is an actin-binding protein that caps the pointed ends of actin filaments.
• It blocks both elongation and depolymerization of actin filaments, thereby maintaining filament length and stability.
• The TMOD4/tropomyosin (TM) complex assembles short actin protofilaments, which define the geometry of the membrane skeleton.
• TMOD4 is highly expressed in skeletal muscle, playing a critical role in sarcomere organization and muscle contraction.
• Subcellularly, TMOD4 localizes to the cytoplasm and cytoskeleton.
• The TMOD4 gene undergoes alternative splicing, generating multiple isoforms that may have distinct regulatory functions.
• Identified as a reference proteome by proteomics identification.

Experimental Guidance and Technical Tips

• The immunogen covers the N-terminal region (aa 1-345) of human TMOD4; consider sequence alignment if using species beyond human, mouse, or rat.
• For Western blotting, TMOD4 has a predicted molecular weight of ~39 kDa; use reducing SDS-PAGE conditions and validate with skeletal muscle lysates for strong endogenous expression.
• Due to cross-reactivity with mouse and rat, this antibody may be suitable for rodent model studies; validate in the relevant sample system.
• For ELISA applications, consider using the recombinant immunogen as a positive control.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a trusted one-stop sourcing partner for IVD raw materials, serving diagnostic manufacturers, laboratories, and research institutes worldwide. We offer this high-quality anti-TMOD4 antibody as part of our extensive catalog of validated reagents for cytoskeletal and muscle biology research. Beyond antibodies, CamelBio provides bulk ancillary reagents, custom antibody development, and comprehensive technical consulting to accelerate your project from concept to clinic.